公司介绍 // introduction
上海嘉因生物科技有限公司是以UCLA计算生物学博士王程扬为核心的，专门从事转录调控技术服务的高新技术企业。公司的主要技术服务业务包括表观遗传学，空间转录组和单细胞测序。截止2022年底，公司已经协助客户在Nature,Cell等国际顶尖杂志发表论文近500篇。此外，公司也是上海市专精特新企业，公共实训平台和博士后流动站。
嘉因生物协助发表的代表性论文//article
1. The primordial differentiation of tumor-specific memory CD8+T cells as bona fide responders to PD 1/PD-L1 blockade in draining lymph nodes.Cell ,185(22):4049-4066.e25. (IF:66.85)
2. RNA m6A regulates transcription via DNA demethylation and chromatin accessibility. Nat Genet , 54, 1427–1437. (IF:41.307)
3. Direct chemical reprogramming of human cord blood erythroblasts to induced megakaryocytes that produce platelets[J]. Cell Stem Cell, 29(8): 1229-1245. e7. (IF:25.269)
4. Topoisomerase IIA in adult NSCs regulates SVZ neurogenesis by transcriptional activation of Usp37. Nucleic Acids Res , 50(16): 9319-9338. (IF:19.16)
5. Integrated multi-omics approach revealed cellular senescence landscape[J]. Nucleic Acids Research, 50(19): 10947-10963. (IF:19.16)
6. Excessive branched-chain amino acid accumulation restricts mesenchymal stem cell-based therapy efficacy in myocardial infarction[J]. Signal Transduction and Targeted Therapy, 7(1): 171. (IF:18.187)
7. The 3D architecture of the pepper genome and its relationship to function and evolution[J]. Nat Comm, 2022, 13(1): 3479. (IF:17.649)
8. Multiomics Analysis Identifies SOCS1 as Restraining T Cell Activation and Preventing Graft‐Versus‐Host Disease[J]. Advanced Science, 9(21): 2200978. (IF:16.806)
9. Bilineage embryo-like structure from EPS cells can produce live mice with tetraploid trophectoderm[J]. Protein Cell, (IF:15.328)
10. Malfunction of airway basal stem cells plays a crucial role in pathophysiology of tracheobronchopathia osteoplastica[J]. Nature Communications, 2022, 13(1): 1309. (IF:17.649)
11. Dissecting super-enhancer driven transcriptional dependencies reveals novel therapeutic strategies and targets for group 3 subtype medulloblastoma[J]. Journal of Experimental & Clinical Cancer Research , 41(1): 311. (IF: 12.658)
12. m6A demethylase ALKBH5 drives denervation‐induced muscle atrophy by targeting HDAC4 to activate FoxO3 signalling[J]. Journal of Cachexia, Sarcopenia and Muscle , 13(2): 1210-1223. (IF:12.603)
13. PRMT5 regulates RNA m6A demethylation for doxorubicin sensitivity in breast cancer[J]. Molecular Therapy , 30(7): 2603-2617. (IF:11.454)
14. H3K27 methylation regulates the fate of wo cell lineages in male gametophytes[J]. The Plant Cell, 34(8): 2989-3005. (IF:11.277)
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